Postnatal Effects of Maternal Exposure to 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD)
نویسندگان
چکیده
منابع مشابه
Postnatal effects of maternal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).
Previous studies reported that subcutaneous administration of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) at a dose level of 3 ,pg/kg, in mice on days 6 through 15 of gestation produced pups with cleft palates and kidney anomalies (1). The C57B1/6 mouse was the most sensitive of the three strains tested to the TCDD-induced kidney effects, in that almost 100%o of the fetuses developed kidney anom...
متن کاملGestational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) severely alters reproductive function of female hamster offspring.
Low doses of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), administered as a single dose to the dam during gestation, alter development of the fetal rodent reproductive system. In male rat and hamster offspring, dosing with TCDD during gestation reduces epididymal and ejaculated sperm counts and delays puberty. In female rats, in utero TCDD-exposure results in reduced ovarian weight and fecundity...
متن کاملExposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is associated with hyperinsulinemia and insulin resistance.
High exposures of Vietnam veterans to 2,3,7, 8-Tetrachlorodibenzo-p-dioxin, a dioxin contained in the herbicide mixture Agent Orange, have previously been demonstrated to be associated with an increased prevalence of diabetes and hyperinsulinemia in non-diabetic subjects. Sixty-nine persons were identified who were in good health and had normal glucose levels during glucose tolerance testing. T...
متن کاملProteomic analysis of human keratinocyte response to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure.
Chronic exposure to 2,3,7,8-tetrachlorodibeno-p-dioxin (TCDD) and related polyhalogenated organic pollutants occurs as a consequence of modern life. Exploring the cellular basis for their action is anticipated to help understand the risk they pose and improve the foundation for their regulation. A basis for the striking change in human keratinocyte colony morphology due to TCDD exposure has bee...
متن کاملToxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in aquatic organisms.
Herbicides are particularly important in modern forest management as foresters attempt to make fullest use of a constantly shrinking production base. In forestry, (2,4,5,-T) 2,4,5-trichloro-phenoxyacetic acid is used to control undesirable woody species that compete with more desirable timber-producing conifers for light, space, moisture, and nutrients. Herbicide applications can result in mark...
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ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 1973
ISSN: 0091-6765
DOI: 10.2307/3428116